Combining Electroacupuncture With Antiemetic Therapy for Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer: A Clinical Study

Status: Recruiting
Location: See location...
Intervention Type: Device, Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This study explores the effectiveness of combining electroacupuncture with olanzapine-containing four-drug antiemetic therapy to mitigate chemotherapy-induced nausea and vomiting (CINV) in patients with breast cancer. The research aims to assess the adjunctive benefits of electroacupuncture in enhancing the antiemetic effects of conventional medication, particularly in the context of highly emetogenic chemotherapy regimens. By investigating the synergistic potential of these modalities, the study seeks to provide insights into optimizing supportive care strategies for patients with breast cancer undergoing intensive chemotherapy treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: t
View:

• Patients aged 18 to 75 years, inclusive, from any nationality.

• Patients diagnosed with early-stage breast cancer.

• Eastern Cooperative Oncology Group performance status ranging from 0 to 2.

• All patients must undergo highly emetogenic chemotherapy (HEC).

• Adequate organ function.

• Adequate contraception required for premenopausal women.

Locations
Other Locations
China
Second Hospital of Lanzhou University
RECRUITING
Lanzhou
Contact Information
Primary
Feixue Song, Dr
13639336037@139.com
13639336037
Time Frame
Start Date: 2024-03-07
Estimated Completion Date: 2027-03-31
Participants
Target number of participants: 370
Treatments
Experimental: True Acupuncture Combined with Antiemetic Therapy
Participants in this arm will undergo electroacupuncture sessions once daily from day 1 to day 4. Electrical stimulation will be administered for 30 minutes at alternating frequencies of 2/10Hz.
Placebo_comparator: Antiemetic therapy
Participants assigned to this arm will receive sham electroacupuncture sessions daily from day 1 to day 4, mirroring the schedule of the experimental group. They will also receive the same antiemetic medications as the experimental group.
Related Therapeutic Areas
Sponsors
Leads: Feixue Song

This content was sourced from clinicaltrials.gov